7 edition of Cellular and Molecular Mechanisms of Drugs of Abuse found in the catalog.
June 1996 by New York Academy of Sciences .
Written in English
|Contributions||Syed F. Ali (Editor), Yasuo Takahashi (Editor)|
|The Physical Object|
|Number of Pages||452|
For years, several molecular mechanisms have been proposed to account for neurotoxic properties of METH, including oxidative stress and apoptosis in dopaminergic cell lines. Recently, an increasing number of studies have reported that autophagy, a self-degradative process, also plays a role in the process of METH-induced cell injury [ 74, 75 ].Cited by: Biosystems Based on Molecular Recognition Processes (AIP Conference Proceedings) Molecular and Cellular Mechanisms of Alcohol and Anesthetics (Annals of the New York Academy of Sciences) Cellular and Molecular Mechanisms of Drugs of Abuse II: Cocaine, Substituted Amphetamines, Gbh, and Opiates (Annals of the New York Academy of Sciences) (v. Find many great new & used options and get the best deals for Methods in Molecular Medicine: Drugs of Abuse: Neurological Reviews and Protocols 79 (, Hardcover) at the best online prices at eBay! Free shipping for many products!
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Sayed Ali and Francesce Fornai are the authors of Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines, Annual of The NY Academy of Science, Volumepublished by : Paperback.
Cellular and Molecular Mechanisms of Drugs of Abuse: Cocain, Ibogaine, and Substituted Amphetamines (Annals of the New York Academy of Sciences) illustrated edition by Syed F. Ali (Editor), Yasuo Takahashi (Editor)Format: Hardcover.
Exposure to drugs of abuse is for most individuals a reinforcing experience which can lead to continued use and the development of an addiction disorder. Evidence indicates that the escalation in use and ultimately compulsive motivation to obtain drug is linked to long lasting cellular changes within the brain reward neurocircuitry.
In this chapter we will describe the transition in use from. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up Author: Sherrel Howard.
Exposure to drugs of abuse can be a reinforcing experience that, in vulnerable individuals, can lead to continued use and the development of an addiction disorder.
Evidence indicates that the escalation in use and compulsive motivation to obtain the drug is linked to long-lasting cellular changes within the brain reward neurocircuitry.
In this chapter we describe the stages of transition in. Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse.
Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. Keywords: Drug dependence, cellular mechanism, receptors, neurotransmitters Human addictions are chronically relapsing disorders characterized by compulsive drug use, an inability to limit the intake of drugs and the emergence of a withdrawal syndrome during cessation of drug use.
Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction.
This chapter describes the mechanism of action for the following classes of drugs of abuse: alcohol, cannabinoids, hallucinogens, inhalants, nicotine, opioids, sedative hypnotics, and stimulants.
In addition, mechanisms of tolerance and withdrawal are : Lindsay M. McCracken, Mandy L. McCracken, R. Adron Harris. Cellular and molecular mechanisms of drugs of abuse and neurotoxicity: cocaine, GHB, and substituted amphetamines. edited by Syed F. Ali and Francesco Fornai. Boston, Mass.: Published by Blackwell Pub.
on behalf of the New York Academy of Sciences, xvi. Drugs of abuse decrease the size of VTA dopamine neurons by depriving the neurons of a crucial nerve growth factor, BDNF (brain-derived neurotrophic factor): • Chronic drug exposure decreases BDNF signaling in the VTA. • Loss of BDNF signaling mediates the decrease in VTA cell size and impairs reward behavior.
Cellular and molecular mechanisms of drug dependence: An overview and update Article (PDF Available) in Indian Journal of Psychiatry 49(2) April with. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons.
This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems.
Common cellular and molecular mechanisms in obesity and drug addiction Paul J. Kenny 1 Nature Reviews Neuroscience vol pages – () Cite this articleCited by: In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.
Receptor sites have specific affinities for drugs based on the chemical structure of the. Cellular and molecular mechanisms of drugs of abuse: cocaine, ibogaine, and substituted amphetamines. Reviews “Cell Biology of Addiction, a groundbreaking and comprehensive book, describes exquisite and rigorous scientific inquiry into the molecular and cellular underpinnings of addiction, examining, as Bertha K.
Madras states in the introduction, ‘genetic influences, biological targets of drugs, neurotoxicity, and the signaling pathways that trigger neuroadaptive processes to drive or.
Proceedings of the Symposium Cellular and Molecular Mechanisms of Drugs of Abuse Cocaine and Methamphetamine held in Nice, France, August 19–20, A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development.
It bridges the gap between cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book presents state-of-the-art technical information and critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level.
" Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines by Yasuo Takahashi; Syed F. Ali A copy that has been read, but remains in excellent condition.
Pages are intact and are not marred by notes or highlighting, but may contain a neat previous owner name.
The spine remains undamaged. Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of Brand: Wiley.
ISBN: OCLC Number: Notes: "Result of a meeting entitled Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB and Substituted Amphetamines, and held on August 16. Systemic Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders Content This book presents results of current research conducted in the I.
Beritashvili Center of Experimental Biomedicine (former I. Beritashvili Institute of Physiology, Tbilisi, Georgia) and is devoted to the experimental investigation of systemic, cellular and molecular mechanisms of physiological.
spective, drug abuse continues to exact enormous human and financial costs on society, yet all currently available treatments for drug addiction are notoriously ineffective. The search for a better understanding of the neurobiological mechanisms un- derlying the addictive actions of drugs of abuse Cited by: In contrast to the initial rewarding effects of cocaine, as measured by CPP and self-administration procedures in rodents with limited histories of exposure to the drug, the cellular mechanisms in the dorsal striatum that drive escalation of cocaine intake under extended access conditions are much less well by: The essential difference between drug abuse and drug dependence is that the latter is a medical disease characterized by a loss of control over drug use and drug seeking (DSM-IV, DSM-V [4,5]).
The above suggests and the literature has demonstrated that clinically there are two sub-populations of people who use drugs: drug abusers and drug Author: Richard Wilcox, Joseph D.
Miller, Ommega Internationals. Book Description. Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain.
Drugs can be classified as agonists, partial agonists, inverse agonists, partial inverse agonists, or antagonists. Modern neuropharmacology takes advantage of the tools of molecular biology, genetics, and cell biology as well as combinatorial chemistry, which is used to generate novel molecules that may function as new drugs.
Book, Print, Conference in English Current status of drug dependence/abuse studies: cellular and molecular mechanisms of drugs of abuse and neurotoxicity edited by Syed F. Ali, Toshitaka Nabeshima, and Tomoji Yanagita.
New York, N.Y.: New York Academy of. A new text book, “Cellular Microbiology”, is evidence for the success of the combined approach. The book describes the fundamental cellular mechanisms that can fall prey to bacteria or bacterial products such as signal transduction, membrane trafficking and organelle biogenesis, cytoskeletal dynamics, cell adhesion, and the regulation of Cited by: 1.
The Molecular Mechanisms of Cellular Stress and Inflammation Section studies the role of endoplasmic reticulum stress and inflammation in neuronal dysfunction caused by substance abuse or neurodegenerative diseases. The cellular mechanisms of aging described above may provide a convincing account of the cellular processes that determine the length of survival and fate of a cell as individuals grow older.
Accumulated molecular and cellular damage by UV, ROS, Ca 2+, and changes in genomic function can be demonstrated in aging cells. Previous studies have suggested that drug use in addiction and overeating in obesity share common cellular and molecular mechanisms (Kenny ). Eating is intrinsically rewarding and reinforcing.
One of the most dramatic advances in drug abuse research has been the identification of the target of every major drug of abuse. This advance occurred with the advent of radioligand-binding techniques, the biochemical characterization of drug binding sites and ultimately, with the application of molecular biology to clone and isolate these.
Table of contents for Cellular and molecular mechanisms of drugs of abuse and neurotoxicity: cocaine, GHB, and substituted amphetamines / edited by Sayed Ali, Francesco Fornai, and Yossef Itzhak. Bibliographic record and links to related information available from the.
The term drug receptor or drug target denotes the cellular macromolecule or macromolecular complex with which the drug interacts to elicit a cellular response, i.e., a change in cell function.
Drugs commonly alter the rate or magnitude of an intrinsic cellular response rather than create new responses.
Download Ebook Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy (Advances in Experimental Medicine pdf Free Download medical books free This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic.
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE COCAINE, D5OGAINE, AND SUBSTITUTED AMPHETAMINES Ibogaine-Induced Purkinje Cell Loss. By A. SCALLET, X. YE, and S. ALI Part VI: Pre- and Postnatal Exposure of Drugs of Abuse Drug Targets in the Embryo: Studies on the Cocaine- and Antidepressant-Sensitive Serotonin Transporter.
Title: Cellular Mechanisms of Striatum-Dependent Behavioral Plasticity and Drug Addiction VOLUME: 2 ISSUE: 7 Author(s):Stephania Fasano and Riccardo Brambilla Affiliation:San Raffaele Research Institute and University, via Olgett Milano, Italy Keywords:drug addiction, behavioral plasticity, striatum-dependent plasticity, parkinson disease, reward-based stimulus-responseCited by:.
Since addiction is a chronic, relapsing condition, this disorder has been notoriously difficult to manage. A complete review of pharmacological mechanisms of drugs of abuse understanding of the molecular, physiological, and behavioral mechanisms involved in the disorder is necessary for the discovery and implementation of more effective : Robert J Oliver, Nora I Perrone-Bizzozero.Drugs of abuse affect the VTA-NAc pathway with a power and persistence not seen in response to natural rewards.
One likely mechanism of addiction, then, is that repeated, extreme perturbation of these neurons changes them in a way that leads to dramatic alterations in reward mechanisms and motivational state that underlie addiction.Common cellular and molecular mechanisms in obesity and drug addiction.
The hedonic properties of food can stimulate feeding behaviour even when energy requirements have been met, contributing to weight gain and obesity.
Similarly, the hedonic effects of drugs of abuse can motivate their excessive intake, culminating in addiction. Common brain substrates regulate the hedonic properties [ ].